Experts Advancing Global Health

Hero Image
Photo of Graham Simmons, Ph.D.

Graham Simmons, Ph.D.

Senior Investigator, Virology

Graham Simmons, Ph.D., is a senior investigator at Vitalant Research Institute (VRI) and an adjunct associate professor at the University of California, San Francisco (UCSF).  Dr. Simmons has worked on various aspects of viral entry and virus:host interactions for over 25 years, beginning with a Ph.D. under the mentorship of Dr. Paul Clapham and Prof. Robin Weiss at the Institute of Cancer Research in London studying various aspects of HIV interactions with chemokine receptors and chemokines. Following an EMBO longterm fellowship funded position with Prof. Paul Bates at University of Pennsylvania studying attachment and processing factors of Ebola and coronavirus entry, Dr. Simmons established his laboratory at VRI focused on emerging and remerging viruses.

Current Positions

Senior Investigator, VRI, San Francisco, California 

Adjunct Assistant Professor, UCSF

Links

University of California, San Francisco Profile

Education & Training

B.S., Microbiology and Virology, University of Warwick, UK 

M.S., Immunology, King’s College London, UK 

Ph.D., Institute of Cancer Research, London, UK 

Post-doctoral fellow, Perelman School of Medicine at the University of Pennsylvania 

Publications

Publications in NLM’s PubMed 

Publications in Google Scholar 

Research Interest

The longtime focus of the Simmons lab has been on emerging and reemerging human viruses, from Ebola and SARS-CoV through to the current Zika virus epidemic. We have developed and optimized a number of serological assays, particularly focusing on virus neutralization, to aid in studies of the prevalence and incidence of emerging viruses in the blood donor population. A second area of interest focuses on the molecular mechanisms of viral entry and egress. We are using this information to identify targets for small molecules and antibodies to inhibit such processes. Finally, we are exploiting our unique access to acute samples that blood banking offers, to characterize the B-cell immune responses to many of these viruses. 

Anti-Viral Antibodies
Viral Serology
Viral Entry and Egress