Transfusion Safety Research

These studies are based upon large research databases including millions of blood donations which can be used for studies of viral prevalence and incidence, including HTLV-1, HTLV-2 and hepatitis C virus. As transfusion-transmitted infections have been controlled, other transfusion complications have been studied including: HLA antibody prevalence in blood donors and their relation to transfusion-related lung injury (TRALI) and iron balance and red cell production in donors. Dr. Murphy has focused recently on determining risk factors for transfusion-associated circulatory overload (TACO), a serious but under-recognized complication of blood transfusions (See Table 3 Murphy EL Am J Med 2013;126:357). A related area of research may be termed “blood donor epidemiology” in which blood donation behavior and frequency are studied using randomized trial designs and survival analysis. Finally, body mass index and anemia prevalence of blood donors are used to model the obesity and anemia in the US general population after adjusting for differences in demographic composition.

Selected Publications:

Murphy EL, Watanabe K, Nass CC, Ownby H, Williams A, Nemo G. Evidence among blood donors for a 30-year old epidemic of HTLV-II infection in the United States. J Infect Dis 1999;180:1777-83.

Carneiro-Proietti AB, Sabino EC, Leão S, Salles NA, Loureiro P, Sarr M, Wright D, Busch M, Proietti FA, Murphy EL for The NHLBI Retrovirus Epidemiology Donor Study-II International Component. Human T-Lymphotropic Virus Type 1 and Type 2 Seroprevalence, Incidence, and Residual Transfusion Risk Among Blood Donors in Brazil During 2007-2009. AIDS Res Hum Retroviruses 2012;28:1265-1272. Epub 2012 May 3. PMCID: PMCPMC3448098

Murphy EL, Bryzman S, Williams AE, Co Chien H, Schreiber GB, Ownby HE, Gilcher RO, Kleinman SH, Matijas L, Thomson RA, Nemo GJ. Demographic determinants of hepatitis C virus (HCV) seroprevalence in United States Blood Donors. JAMA 1996;275:995-1000.

Murphy EL, Fang J, Tu Y, Cable R, Hillyer CD, Sacher R, Triulzi D, Gottschall JL, Busch MP for the Retrovirus Epidemiology Donor Study II (REDS-II). Hepatitis C virus prevalence and clearance among U.S. blood donors, 2006-2007: associations with birth cohort, multiple pregnancies and body mass index. J Infect Dis 2010;202:576-584. PMCID: PMC2932782

de Almeida-Neto C, Sabino ES, Liu J, Blatyta PF, Mendrone A, Salles NA, Ledo SC, Wright DJ, Basques FV, Ferreira JE, Busch MP, Murphy EL. Prevalence of serologic markers for hepatitis B and C viruses in Brazilian blood donors and incidence and residual risk of transfusion transmission of hepatitis C virus. Transfusion 2013;53:827-834. PMCID: PMC3499633

Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD,Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney MR, Kakaiya RM; for the National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II). The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion 2011;51:2078-91. Epub 2011 Mar 29.

Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PH, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion related acute lung injury: incidence and risk factors. Blood 2012;119:1757-67.

Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P and the TRALI Study Group. Risk factors and outcomes in transfusion-associated circulatory overload (TACO). Am J Med 2013;126:357.e29-38. PMCID: PMC3652681

Cable RG, Glynn Sa, Kiss JE, Mast AE, Steele WR, Murphy EL, Wright DJ, Sacher RA, Gottschall JL, Tolber LH, Simon TL; for the NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II). Iron deficiency in blood donors: the REDS-II Donor Iron Status Evaluation (RISE) study. Transfusion 2012;52:702-11. Epub 2011 Oct 24.

Reich P, Roberts P, Laabs N, Chinn A, McEvoy P, Hirschler N, Murphy EL. A randomized trial of blood donor recruitment strategies. Transfusion 2006;46:1090-96.

Schlumpf KS, Glynn SA, Schreiber GB, Wright DJ, Randolph Steele W, Tu Y, Hermansen S, Higgins MJ, Garratty G, Murphy EL; National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study. Factors influencing donor return. Transfusion 2008;48:264-72. Epub 2007 Nov 13.

Nguyen DD, DeVita DA, Hirschler NV, Murphy EL. Blood donor satisfaction and intention of future donation. Transfusion 2008;48:742-8. Epub 2008 Jan 8. PMCID: PMC2846752

Murphy EL, Schlumpf K, Wright D, Cable R, Roback J, Sacher R, Busch MP. Body mass index and obesity in U.S. blood donors: a potential public health role for the blood center. Public Health Nutrition 2012;15:964-71. PMCID: PMC3518631

Mast AE, Steele WR, Johnson B, Wright DJ, Cable RG, Carey P, Gottschall JL, Kiss JE, Simon TL, Murphy EL. Population-based screening for anemia using first-time blood donors. Am J Hematol 2012;87:496-502. Epub 2012 Mar 28. PMCID: PMC3525330