Pulmonary Transfusion Reactions

Utilizing inflammatory cytokines in addition to a limited set of clinical predictors, we were able to effectively distinguish the etiology of transfusion-related pulmonary edema using regression models. We continue to study cardiopulmonary biomarkers as well as markers of endothelial injury diagnostically to better understand the pathophysiology of these adverse events. As part of this same work, we are examining the role of donor factors (age and gender) as well as modifications to blood components (washing and irradiation) in the development of adverse pulmonary reactions. While the focus of these studies is on adverse reactions, they also provide the opportunity to study clinical and laboratory markers of potential benefit in transfused patients with severe anemia or coagulopathy.

Selected Publications:

Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr R, Lowell CA et al for the TRALI Study Group. Clinical Course and Outcomes in Transfusion-Related Acute Lung Injury. Crit Care Med. 2014 Jul;42(7):1676-87.

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD et al for the TRALI Study Group. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Feb 23.

Roubinian N and Murphy EL. Transfusion-associated circulatory overload (TACO): prevention, management and patient outcomes. International Journal of Clinical Transfusion Medicine. 2015 Apr:3:17-28.

Hendrickson JE, Roubinian N, Chowdhury D, Brambilla D, Murphy EL, Wu Y et al for the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Incidence of transfusion reactions: a multicenter study utilizing active surveillance and expert adjudication. Transfusion. 2016 Jul 26.

Roubinian N, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury C, Kor DJ et al for the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Incidence and clinical characteristics of TACO using an active surveillance algorithm. Vox Sanguinis. 2017 Jan;112(1):56-63.

Roubinian NH, Looney MR, Keating S; Kor DJ, Lowell CA, Gajic O et al for the TRALI Study Group. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion. 2017 in press.