Impact of Transfusion on Blood Recipients
 

Example of Recent Work:
Another example of recent work was a large transfusion-transmission study of dengue virus in Brazil. This study was conducted at blood centers and hospitals in Rio de Janeiro and Recife, Brazil. Both blood donors and recipients were enrolled (see Figure). In this study we found evidence that over 1/3 of blood units with dengue virus transmitted infection to recipients, but medical chart review did not find evidence of significant differences in symptoms or mortality between cases with dengue and controls without dengue.(References 5-7 ) We are currently investigating chikungunya and Zika infections in donors in Brazil and assessing risks of transfusion-transmission using similar study designs.

Selected Publications:

Carneiro-Proietti ABF, Kelly S, Miranda Teixeira C, Sabino EC, Alencar CS, Capuani L, Salomon Silva TP, Araujo A, Loureiro P, Máximo C, Lobo C, Flor-Park MV, Rodrigues DOW, Mota RA, Gonçalez TT, Hoppe C, Ferreira JE, Ozahata M, Page GP, Guo Y, Preiss LR, Brambilla D, Busch MP, Custer B; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Clinical and genetic ancestry profile of a large multi-centre sickle cell disease cohort in Brazil. Br J Haematol. 2018 Sep;182(6):895-908. doi: 10.1111/bjh.15462. Epub 2018 Jul 19.

Blatyta PF, Kelly S, Sabino E, Preiss L, Mendes F, Carneiro-Proietti AB, Werneck Rodrigues DO, Mota R, Loureiro P, Maximo C, Park M, Mendrone-Jr A, Gonçalez TT, de Almeida Neto C, Custer B; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study III (REDS-III) International Component, Brazil. Prevalence of serologic markers of transfusion and sexually transmitted infections and their correlation with clinical features in a large cohort of Brazilian patients with sickle cell disease. Transfusion. 2020 Feb;60(2):343-350. doi: 10.1111/trf.15619.

Cintho Ozahata M, Page GP, Guo Y, Ferreira JE, Dinardo CL, Carneiro-Proietti ABF, Loureiro P, Mota RA, Rodrigues DOW, Belisario AR, Maximo C, Flor-Park MV, Custer B, Kelly S, Sabino EC; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Clinical and Genetic Predictors of Priapism in Sickle Cell Disease: Results from the Recipient Epidemiology and Donor Evaluation Study III Brazil Cohort Study. J Sex Med. 2019 Dec;16(12):1988-1999. doi: 10.1016/j.jsxm.2019.09.012.

Dinardo CL, Kelly S, Dezan MR, Ribeiro IH, Castilho SL, Schimidt LC, Valgueiro MDC, Preiss LR, Custer B, Sabino EC, Westhoff CM; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III. Diversity of RH and transfusion support in Brazilian sickle cell disease patients with unexplained Rh antibodies. Transfusion. 2019 Oct;59(10):3228-3235. doi: 10.1111/trf.15479. Epub 2019 Aug 13.

Sabino EC, Loureiro P, Lopes ME, Capuani L, McClure C, Chowdhury D, Di-Lorenzo-Oliveira C, Oliveira LC, Linnen JM, Lee TH, Gonçalez T, Brambilla D, Kleinman S, Busch MP, Custer B. Transfusion-Transmission of Dengue Virus and Associated Clinical Symptomatology during the 2012 Epidemic in Brazil. J Infect Dis. 2016 Mar 1;213(5):694-702. doi: 10.1093/infdis/jiv326.

Busch MP, Sabino EC, Brambilla D, Lopes ME, Capuani L, Chowdhury D, McClure C, Linnen JM, Prince H, Simmons G, Lee TH, Kleinman S, Custer B; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).Duration of Dengue Viremia in Blood Donors and Relationships Between Donor Viremia, Infection Incidence and Clinical Case Reports During a Large Epidemic. J Infect Dis. 2016 Jul 1;214(1):49-54. doi: 10.1093/infdis/jiw122.

Faria NR, da Costa AC, Lourenço J, Loureiro P, Lopes ME, Ribeiro R, Alencar CS, Kraemer MUG, Villabona-Arenas CJ, Wu CH, Thézé J, Khan K, Brent SE, Romano C, Delwart E, Custer B, Busch MP, Pybus OG, Sabino EC; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil. Sci Rep. 2017 Nov 9;7(1):15216. doi: 10.1038/s41598-017-15152-8.