Larry J. Dumont, MBA, PhD

Director, VRI-Denver
Senior investigator

 

Larry J. Dumont, MBA, PhD

Profile

Larry J. Dumont, MBA, PhD is the Director and Senior Investigator at the Vitalant Research Institute at its campus extension in Denver, Colorado. He is Adjunct Associate Professor at the Geisel School of Medicine at Dartmouth. Dr. Dumont spent 27 years at GAMBRO BCT and 10 years at Dartmouth. He received his BS at Regis College, MBA at University of Phoenix and PhD in Clinical Sciences from the University of Colorado. He is the immediate past Chair of the Biomedical Excellence for Safer Transfusion Collaborative (BEST). His current interests are in platelet and red blood cell physiology, cryopreservation of platelets, in vivo cell survival kinetics, and clinical outcomes in transfusion medicine. Dr. Dumont has been an invited speaker at FDA advisory meetings and various national and international congresses.

Larry J. Dumont, MBA, PhD
Vitalant Research Institute
717 Yosemite Street
Denver, CO 80230
 
Phone: (303) 363-2401

  • Director and Senior Investigator, Vitalant Research Institute, Denver, Colorado
  • Adjunct Associate Professor at the Geisel School of Medicine at Dartmouth
  • BS Biology, Regis College, Denver, CO
  • MBA, University of Phoenix, Denver, CO
  • PhD Clinical Sciences, University of Colorado, Denver, CO
Deborah F. Dumont, MT(ASCP)SBB

Deborah F. Dumont, MT(ASCP)SBB
Medical Technologist II – Lead Technologist
 
Phone: (303) 363-2452

Timothy L. Gehris MT(ASCP), CQA(ASQ)

Timothy L. Gehris MT(ASCP), CQA(ASQ)
Quality Manager
 
Phone: (303) 363-2453

Kathleen Kelly, PhD

Kathleen Kelly, PhD
Staff Scientist I
 
Phone: (303) 363-2459

Nathan Liss

Nathan Liss, BS
Research Assistant
 
Phone: (303) 363-2395

Marc Strong, MT(ASCP)

Marc Strong, MT(ASCP)
Medical Technologist II
 
Phone: (303) 363-2423

Larry J. Dumont, MBA, PhD
Vitalant Research Institute
717 Yosemite Street
Denver, CO 80230
 
Phone: (303) 363-2401

  • Director and Senior Investigator, Vitalant Research Institute, Denver, Colorado
  • Adjunct Associate Professor at the Geisel School of Medicine at Dartmouth
  • BS Biology, Regis College, Denver, CO
  • MBA, University of Phoenix, Denver, CO
  • PhD Clinical Sciences, University of Colorado, Denver, CO
Deborah F. Dumont, MT(ASCP)SBB

Deborah F. Dumont, MT(ASCP)SBB
Medical Technologist II – Lead Technologist
 
Phone: (303) 363-2452

Timothy L. Gehris MT(ASCP), CQA(ASQ)

Timothy L. Gehris MT(ASCP), CQA(ASQ)
Quality Manager
 
Phone: (303) 363-2453

Kathleen Kelly, PhD

Kathleen Kelly, PhD
Staff Scientist I
 
Phone: (303) 363-2459

Nathan Liss

Nathan Liss, BS
Research Assistant
 
Phone: (303) 363-2395

Marc Strong, MT(ASCP)

Marc Strong, MT(ASCP)
Medical Technologist II
 
Phone: (303) 363-2423

Research Interests

 

The Dumont laboratory has historically focused on evaluation of new products for the preparation and delivery of blood products to patients. Evaluations include in vitro characterization, design and execution of early clinical trials, and participation in pivotal trials for regulatory approvals. Now at VRI-Denver, the laboratory is on the way to becoming the leading institute for research and translational development of new, modified, and novel blood components for the transfusion medicine community. Our leading project is development of DMSO cryopreserved platelets. We are also interested in gaining deeper understandings of the biology and physiology of the platelet and red blood count (RBC), relating in vitro measures such as metabolic profiles to in vivo outcomes, and identifying potential targets for processing interventions.

Cryopreservation of Platelets

Platelets for transfusion are stored at 22°C with a 5 – 7 day shelf life. This often severely limits availability in remote care locations and even in large urban areas. Our program, supported through the Department of Defense, has developed cGMP manufacturing processes for the preparation, storage, and distribution of a 6% DMSO, no-wash, cryopreserved platelet (CPP). We continue to characterize the in vitro properties of the CPP and support all clinical trials in the United States.

Platelet and Red Blood Cell Biology and Physiology

Characterization and understanding the biology and physiology of platelets and RBCs will assist in the development of new methods of collection, treatment, storage and delivery for these products. This understanding may also inform the in vivo effects once transfused in terms of safety and efficacy. Work in this area has included describing the metabolic response of cells under various conditions and donor associations with cell phenotypes, and evaluating new methods and procedures.