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Modeling of transfusioN

 

The Cell Therapy Core has helped to develop in vivo models to examine the effects of transfusion on the immune system.  An ongoing focus is on the effects of pathogen inactivation technology on reducing the immunogenicity of blood products.  We have also contributed to the evaluation of human blood products in xenogeneic in vivo models.

 

Selected Publications:

 

Jackman RP, Utter GH, Muench MO, Heitman JW, Munz MM, Jackman RW, Biswas HH, Rivers RM, Tobler LH, Busch MP, Norris PJ. Distinct roles of trauma and transfusion in induction of immune modulation after injury. Transfusion. 2012;52:2533-2550. PMC3392528

 

Jackman RP, Muench MO, Heitman JW, Inglis HC, Law JP, Marschner S, Goodrich RP, Norris PJ. Immune modulation and lack of alloimmunization following transfusion with pathogen-reduced platelets in mice. Transfusion. 2013;53:2697-2709.

 

Danesh A, Inglis HC, Jackman RP, Wu S, Deng X, Muench MO, Heitman JW, Norris PJ. Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro. Blood. 2014;123:687-696. PMC3907755

 

Potter DR, Baimukanova G, Keating SM, Deng X, Chu JA, Gibb SL, Peng Z, Muench MO, Fomin ME, Spinella PC, Kozar R, Pati S. Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock. J Trauma Acute Care Surg. 2015;78:S7-S17.
 

Baimukanova G, Miyazawa B, Potter DR, Gibb SL, Keating S, Danesh A, Beyer A, Dayter Y, Bruhn R, Muench MO, Cap AP, Norris PJ, Spinella P, Cohen M, Pati S. The effects of 22°C and 4°C storage of platelets on vascular endothelial integrity and function. Transfusion. 2016;56 Suppl 1:S52-S64.

 

Baimukanova G, Miyazawa B, Potter DR, Muench MO, Bruhn R, Gibb SL, Spinella PC, Cap AP, Cohen MJ, Pati S. Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets. Transfusion. 2016;56 Suppl 1:S65-S75.

 

Muench MO, Heitman JW, Inglis H, Fomin ME, Marschner S, Goodrich RP, Norris PJ, Jackman RP. Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets. Transfusion. 2016;56:1419-1429.

 

Jackman RP, Muench MO, Inglis H, Heitman JW, Marschner S, Goodrich RP, Norris PJ. Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood. Transfusion. 2017;57:(12 pages). doi:10.1111/trf.13895