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Larry J. Dumont, MBA, PhD

Director, VRI-Denver
Senior investigator

 

Larry J. Dumont, MBA, PhD is the Director and Senior Investigator at the Vitalant Research Institute at its campus extension in Denver, Colorado. He is Adjunct Associate Professor at the Geisel School of Medicine at Dartmouth. Dr. Dumont spent 27 years at GAMBRO BCT and 10 years at Dartmouth. He received his BS at Regis College, MBA at University of Phoenix and PhD in Clinical Sciences from the University of Colorado. He is the immediate past Chair of the Biomedical Excellence for Safer Transfusion Collaborative (BEST). His current interests are in platelet and red blood cell physiology, cryopreservation of platelets, in vivo cell survival kinetics, and clinical outcomes in transfusion medicine. Dr. Dumont has been an invited speaker at FDA advisory meetings and various national and international congresses.

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Larry J. Dumont, MBA, PhD
Vitalant Research Institute
717 Yosemite Street
Denver, CO 80230
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Phone: (303) 363-2401

  • Director and Senior Investigator, Vitalant Research Institute, Denver, Colorado
  • Adjunct Associate Professor at the Geisel School of Medicine at Dartmouth
  • BS Biology, Regis College, Denver, CO
  • MBA, University of Phoenix, Denver, CO
  • PhD Clinical Sciences, University of Colorado, Denver, CO
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Deborah F. Dumont, MT(ASCP)SBB
Medical Technologist II – Lead Technologist
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Phone: (303) 363-2452
 

 
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Timothy L. Gehris MT(ASCP), CQA(ASQ)
Quality Manager
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Phone: (303) 363 - 2453

 
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Kathleen Kelly, PhD
Staff Scientist I
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Phone: (303) 363-2459

 
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Nathan Liss, BS
Research Assistant
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Phone: (303) 363-2395

 
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Marc Strong, MT(ASCP)
Medical Technologist II
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Phone: (303) 363-2423
 

Research Interests

 

The Dumont laboratory has historically focused on evaluation of new products for the preparation and delivery of blood products to patients. Evaluations include in vitro characterization, design and execution of early clinical trials, and participation in pivotal trials for regulatory approvals. Now at VRI-Denver, the laboratory is on the way to becoming the leading institute for research and translational development of new, modified, and novel blood components for the transfusion medicine community. Our leading project is development of DMSO cryopreserved platelets. We are also interested in gaining deeper understandings of the biology and physiology of the platelet and red blood count (RBC), relating in vitro measures such as metabolic profiles to in vivo outcomes, and identifying potential targets for processing interventions.

  • Cryopreservation of Platelets

    Platelets for transfusion are stored at 22°C with a 5 – 7 day shelf life. This often severely limits availability in remote care locations and even in large urban areas. Our program, supported through the Department of Defense, has developed cGMP manufacturing processes for the preparation, storage, and distribution of a 6% DMSO, no-wash, cryopreserved platelet (CPP). We continue to characterize the in vitro properties of the CPP and support all clinical trials in the United States.

  • Platelet and Red Blood Cell Biology and Physiology

    Characterization and understanding the biology and physiology of platelets and RBCs will assist in the development of new methods of collection, treatment, storage and delivery for these products. This understanding may also inform the in vivo effects once transfused in terms of safety and efficacy. Work in this area has included describing the metabolic response of cells under various conditions and donor associations with cell phenotypes, and evaluating new methods and procedures.